Neurofibromatosis Research Tools Central
Building a Robust Research Toolkit
Sharing information about research tools is critical to help the neurofibromatosis (NF) research community discover tools available to enable and support their research. NF Research Tools Central aims to support the development of a robust research toolkit and lower the barrier of entry to NF research. The database includes information on NF-associated animal models, cell lines, antibodies, and genetic reagents; details on tool characteristics and sourcing; as well as observational and experimental data.
Information available in the database has been generously contributed by the research community, as well as aggregated from publicly-available information across several research resource catalogs. Community contributions are encouraged at both the pre-publication and published stages, and may be annotated to indicate various stages of tool development and characterization. Contributors may provide details on tool availability, including any MTA requirements, instructions, and contact information to acquire a particular research tool.
Please note: Contributed information on research tools and associated observations will be made publicly available in NF Research Tools Central. Contributions to the database are welcome at all stages of tool development and characterization. You are encouraged to speak with your institutional technology transfer office prior to sharing any proprietary information to confirm any restrictions on how and when information related to a particular tool may be shared publicly. Non-public information should not be submitted to NF Research Tools Central without permission of the tool developer.
The database currently supports contributions of information about any animal models, cell lines, antibodies, genetic reagents, and biobanks that are related to the study of neurofibromatosis type 1, neurofibromatosis type 2, or schwannomatosis. If you are interested in contributing a research tool to the database, please visit How to Contribute a Tool.
What tools are eligible?
We accept tools that are in any state of development, published or unpublished, as long as you envision sharing this tool to the public. We encourage researchers to submit tools in-development if they are seeking collaborators to help validate and improve the tool.
We accept the following types of tools:
Cell lines: immortalized cell lines or primary cell cultures that exist in a large enough quantity to be shared
Animal models: Genetically modified models of any species as well as well-characterized and shareable xenograft models
Antibodies: Any commercially available or self-distributed antibody for NF-relevant targets
Genetic reagents: Plasmids, guide RNAs, useful primers, or other genetic tools for studying NF
Biobanks: Tissue or other biospecimen repositories with NF tumors or other NF-relevant biospecimens
Citing NF Research Tools Central
To cite NF Research Tools Central, please use the following citation:
Clayton, Ashley, et al. “Centralizing neurofibromatosis experimental tool knowledge with the NF Research Tools Database.” Database (in press). https://doi.org/10.1093/database/baac045
Acknowledgements
When a resource in our database is listed with an RRID, that indicates that some or all of the metadata was obtained from a Research Resource Identifier Initiative member. Licenses and references are described below; please consider citing these upstream repositories as necessary.
Research Resource Identification Initiative
Citation:
Bandrowski A, Brush M, Grethe JS, Haendel MA, Kennedy DN, Hill S, Hof PR, Martone ME, Pols M, Tan SC, Washington N, Zudilova-Seinstra E, Vasilevsky N; RINL Resource Identification Initiative. The Resource Identification Initiative: a cultural shift in publishing. Brain Behav. 2015 Dec 8;6(1):e00417. doi: 10.1002/brb3.417. PMID: 27110440; PMCID: PMC4834942.
AntibodyRegistry.org
Website: http://AntibodyRegistry.org
License: CC-BY-3.0
Citation:
Bandrowski,A. et al. (2011) An antibody registry for biological sciences. In, Front. Neuroinform. Conference Abstract: 4th INCF Congress of Neuroinformatics. doi: 10.3389/conf. fninf.
Cellosaurus
Website: https://web.expasy.org/cellosaurus/
License: CC-BY-4.0
Citation:
Bairoch A. The Cellosaurus, a cell line knowledge resource. J. Biomol. Tech. 29:25-38(2018). DOI: 10.7171/jbt.18-2902-002; PMID: 29805321; PMCID: PMC5945021
Mouse Genome Informatics
Website: http://www.informatics.jax.org/
License: CC-BY-4.0
Citation:
Bult CJ, Blake JA, Smith CL, Kadin JA, Richardson JE, the Mouse Genome Database Group. 2019. Mouse Genome Database (MGD) 2019. Nucleic Acids Res. 2019 Jan. 8;47 (D1): D801–D806.
Mammalian Phenotype Ontology
Website: http://www.informatics.jax.org/mgihome/other/Ontology_Licenses.shtml
License: CC-BY-4.0
Addgene
Website: http://Addgene.org
License: unknown
Citation:
Kamens J. (2015). The Addgene repository: an international nonprofit plasmid and data resource. Nucleic acids research, 43(Database issue), D1152–D1157. https://doi.org/10.1093/nar/gku893